Serendipitous Discovery of a Cascade Approach to Perhydrodibenzofuranones Related to the Natural Product Incarviditone

Autor:	Stephania Christou, Alyn C. Edwards, Ian J. Stratford, Robin G. Pritchard, Roger C. Whitehead, Peter Quayle
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Natural product Incarviditone Cascade reaction chemistry Cascade Stereochemistry Organic Chemistry Lung cancer cell line Combinatorial chemistry Lead compound Sequence (medicine)
Zdroj:	Synlett. 25:1263-1266
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0033-1341081
Popis:	The unexpected discovery of an eliminative deprotection and cyclodimerization cascade reaction sequence led to the preparation of a series of perhydrodibenzofuranones that bear a structural resemblance to the natural product incarviditone. One of the novel dimers was found to show significant antiproliferative activity towards a non-small-cell lung cancer cell line, and represents a useful lead compound for the discovery of more potent anti-cancer agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e0d6b7df5e152e65ef85c789504456d4 https://doi.org/10.1055/s-0033-1341081 Zobrazit plný text záznamu