The reproduction of paradoxical sensitivity to staphylococcal and clostridium welchii toxins

Autor:	I. N. Morgunov, V. V. Khatuntsev
Rok vydání:	1960
Předmět:	Toxin media_common.quotation_subject Stimulation General Medicine Biology medicine.disease_cause complex mixtures General Biochemistry Genetics and Molecular Biology Microbiology Clostridium welchii Immunity Total dose Immunology Blood plasma medicine Reproduction media_common
Zdroj:	Bulletin of Experimental Biology and Medicine. 49:271-273
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00793022
Popis:	The authors attempted to reproduce the Behring phenomenon by repeated administration of sublethal doses of staphylococcal andCl. welchii toxins. This phenomenon could not be reproduced either with a single dose of 1/5 MLD or with a total dose exceeding 2 MLD. No cumulation of the toxin was noted. The fact that there occurred neither the development of the disease nor the death of the animals had nothing to do with the development of antitoxic immunity or the brevity of stimulation best injections with 1-MLD resulted in the death of the animals, while more frequent administration thereof failed to provoke the development of the disease. The authors suggest that the impossibility to reproduce Behring's phenomenon with the toxins under investigation is conditioned by their exzymatic nature and the presence of a free substrate (lecithin) in the blood plasma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e0d46bb90fc9e7ac848f118b898e79d1 https://doi.org/10.1007/bf00793022 Zobrazit plný text záznamu Full text from SpringerLink