| Autor: |
R. L. P. Van Vlierberghe, Gert Jan Fleuren, Peter J. K. Kuppen, Ulf Nannmark, Bengt Johansson, N. G. Ensink, C.J.H. van de Velde, Liesbeth E. Jonges, Per Albertsson |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Scandinavian Journal of Immunology. 53:103-110 |
| ISSN: |
0300-9475 |
| DOI: |
10.1046/j.1365-3083.2001.00838.x |
| Popis: |
Peripheral blood natural killer (NK) cells are usually defined as a homogeneous cell population. However, NK cells show heterogeneous expression of a diversity of cell surface molecules, which might reflect the diversity of NK-cell functions. Therefore, a more specific phenotypic definition of NK cells is necessary. In this study, we made an inventory of phenotypic subsets that are present within the peripheral blood NK-cell population of healthy donors based on differential expression of nine cell-surface markers. Using three-colour flow cytometric analysis we were able to define at least 48 different CD56(+) NK-cell subsets within the peripheral blood. This phenotypic heterogeneity appeared to be stable among healthy individuals, and was also steady within CD56(dim) and CD56(bright) NK populations, indicating a possible role for these subsets in NK-cell function or differentiation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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