A Randomized Comparative Trial of Stavudine (d4T) Versus Zidovudine (ZDV, AZT) in Children With Human Immunodeficiency Virus Infection
Autor: | N. Hutcheon, Sharon Nichols, Jane C. Lindsey, Mary Culnane, R. B. Van Dyke, M. Gwynne, Wendy G. Mitchell, Mark W. Kline, Ram Yogev, Ross E. McKinney |
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Rok vydání: | 1998 |
Předmět: |
medicine.medical_specialty
biology business.industry Lymphocyte Stavudine Neutropenia medicine.disease biology.organism_classification Surgery Zidovudine medicine.anatomical_structure Acquired immunodeficiency syndrome (AIDS) Immunopathology Internal medicine Pediatrics Perinatology and Child Health medicine medicine.symptom business Sida Weight gain medicine.drug |
Zdroj: | Pediatrics. 101:214-220 |
ISSN: | 1098-4275 0031-4005 |
Popis: | Objectives. To compare the safety and tolerance of stavudine (d4T) versus zidovudine (ZDV, AZT) in symptomatic human immunodeficiency virus-infected children 3 months to 6 years of age.Methods. In an initially double-blind trial, 212 evaluable human immunodeficiency virus-infected children who had received no more than 6 weeks of previous antiretroviral therapy were randomized to receive either d4T (1 mg/kg orally every 12 hours, maximum 40 mg orally every 12 hours) or zidovudine (180 mg/m2 orally every 6 hours, maximum 200 mg orally every 6 hours). The study was unblinded after a median follow-up period of 6.3 months; median follow-up at study closure was 17.3 months. Tolerance, safety, disease progression, and immunologic responses were evaluated.Results. The patient population was young (median age, 1.2 years; range, 0.3 to 6.4 years), with a median baseline CD4+ lymphocyte count of 965 cells/μL (range, 18 to 4238 cells/μL). Neutropenia Conclusions. In children between the ages of 3 months and 6 years, d4T and zidovudine are largely comparable in terms of safety and tolerance. Neutropenia occurs significantly less commonly among children treated with d4T. There was evidence that weight gain and absolute CD4+ lymphocyte counts were better maintained in children receiving d4T. |
Databáze: | OpenAIRE |
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