Lipopeptide and zinc oxide nanoparticles blended polyvinyl alcohol-based nanocomposite films as antimicrobial coating for biomedical applications
| Autor: | Jyotishkumar Parameswaranpillai, Aswathy Jayakumar, E. K. Radhakrishnan, Indu C. Nair, Suchart Siengchin, Sabarish Radoor |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0303 health sciences Nanocomposite chemistry.chemical_element Nanoparticle Bioengineering Zinc engineering.material Antimicrobial 01 natural sciences Applied Microbiology and Biotechnology Biochemistry Polyvinyl alcohol Solvent 03 medical and health sciences chemistry.chemical_compound Membrane Coating chemistry Chemical engineering 010608 biotechnology engineering 030304 developmental biology |
| Zdroj: | Process Biochemistry. 102:220-228 |
| ISSN: | 1359-5113 |
| DOI: | 10.1016/j.procbio.2020.12.010 |
| Popis: | Infections caused by the biofilm-forming multi-drug resistant organisms are increasing day by day. In this study, polyvinyl alcohol (PVA) based antimicrobial membranes were developed with the incorporation of lipopeptides (LPs) and zinc oxide nanoparticles (ZnONPs) by solvent casting method. The fabricated membranes were further characterised by the FT-IR, SEM, UV–vis spectroscopy, TGA and mechanical analysis. The results showed enhanced optical, thermal, mechanical and water barrier properties for the membranes engineered with LPs and ZnONPs. The membranes also showed excellent activity against the biofilm-forming bacteria such as the Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa. Also, the developed nanocomposite membranes were found to be hemocompatible with enhanced dressing pH features. Hence, the developed nanocomposite membranes can be considered to have promising biomedical application as antimicrobial coating. |
| Databáze: | OpenAIRE |
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