Chronic hepatitis C virus infection and lymphoproliferative disorders: Mixed cryoglobulinemia syndrome, monoclonal gammopathy of undetermined significance, and B-cell non-Hodgkin lymphoma
| Autor: | Alessia Ciancio, Gian Paolo Caviglia, Maria Lorena Abate, Claudio Sciacca, Antonina Smedile, Chiara Rosso, Antonella Olivero, Giovanni Antonio Touscoz, Mario Rizzetto |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Hepatology business.industry Hepatitis C virus Gastroenterology Lymphoproliferative disorders Odds ratio medicine.disease medicine.disease_cause Virology Lymphoma Liver disease hemic and lymphatic diseases Internal medicine medicine Risk factor business Monoclonal gammopathy of undetermined significance |
| Zdroj: | Journal of Gastroenterology and Hepatology. 30:742-747 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.12837 |
| Popis: | Background and Aim Chronic hepatitis C (CHC) has been associated with lymphoproliferative disorders (LPD) such as mixed cryoglobulinemia syndrome (MCS), monoclonal gammopathy of undetermined significance (MGUS), and B-cell non-Hodgkin lymphoma (B-NHL). The aim of the present study is to assess MCS, MGUS, and B-NHL prevalence in a cohort of CHC-infected patients and to evaluate the association of demographic, clinical, and virologic factors with the presence of LPDs. Methods A total of 121 CHC patients with LPDs (50 M, 71 F; mean age 61.5 ± 11.8) and 130 CHC patients without extrahepatic manifestations (60 M, 70 F; mean age 60.4 ± 9.2) were retrospectively enrolled from a cohort of 1313 CHC patients between January 2006 and December 2013. Patients with LPDs included: 25 patients with MCS (9 M, 16 F; mean age 60.2 ± 1.4), 55 patients with MGUS (18 M, 37 F; mean age 61.3 ± 12.1), and 41 patients with B-NHL (23 M, 18F; mean age 62.5 ± 11.0) Results Patients with MCS (25/1313; 1.9%), MGUS (55/1313; 4.2%), and B-LNH (41/1313; 3.1%) did not differ in age, severity of liver disease, HCV genotype, and response to antiviral therapy. Using multivariate logistic regression analysis, a positive association was found between the presence of cirrhosis and MGUS (odds ratio [OR] = 2.8924, 95% confidence interval [CI] 1.2693–6.5909; P = 0.012) and between cirrhosis and B-NHL (OR = 3.9407, 95%CI 1.7226–9.0153; P = 0.001), whereas no association with MCS diagnosis emerged. Conclusion Despite the pathogenetic mechanism of HCV-associated LPDs is still unclear, cirrhosis is an additional risk factor for the development of lymphoproliferative disorders in patients with chronic HCV infection. |
| Databáze: | OpenAIRE |
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