Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions
| Autor: | W K Jacky Lam, Ann D King, Jacob A Miller, Zhiwei Liu, Kelly J Yu, Melvin L K Chua, Brigette B Y Ma, Ming Yuan Chen, Benjamin A Pinsky, Pei-Jen Lou, John K S Woo, Wan-Lun Hsu, Julia Simon, Denise L Doolan, Tim Waterboer, Edwin P Hui, Hui Li, Raymond K Tsang, Kenneth C W Wong, Julian P Goh, Alexander C Vlantis, Qi Yong Ai, Lun M Wong, Victor Abdullah, Jin Ching Lin, Chien-Jen Chen, Ruth M Pfeiffer, Quynh-Thu Le, Anne W M Lee, Mingfang Ji, Sumei Cao, Jun Ma, Anthony T C Chan, K C Allen Chan, Allan Hildesheim |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | JNCI: Journal of the National Cancer Institute. 115:355-364 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/djad012 |
| Popis: | A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)–based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program. |
| Databáze: | OpenAIRE |
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