Shedding of Angiostrongylus costaricensis larvae in the faeces of Swiss mice experimentally infected with different infective doses
| Autor: | Márcio Machado Costa, C.C. Hermes, E. Benvegnú, Maria Isabel Botelho Vieira, Rubens Rodriguez |
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| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
Larva 030231 tropical medicine Zoonosis General Medicine Biology medicine.disease biology.organism_classification Abdominal angiostrongyliasis Post infection 030308 mycology & parasitology Microbiology 03 medical and health sciences 0302 clinical medicine Nematode parasitic diseases medicine Animal Science and Zoology Parasitology Feces Angiostrongylus costaricensis |
| Zdroj: | Journal of Helminthology. 94 |
| ISSN: | 1475-2697 0022-149X |
| DOI: | 10.1017/s0022149x18000925 |
| Popis: | Abdominal angiostrongyliasis is an endemic zoonosis in southern Brazil caused by the nematode Angiostrongylus costaricensis, which uses terrestrial molluscs as intermediate hosts and wild rodents as final hosts. Humans can be infected by ingesting infectious A. costaricensis larvae. To date, correlations between shedding of first-stage larvae (L1) and different infective doses of third-stage larvae (L3) have not been elucidated. The aim of this study was to assess L1 faecal shedding levels in Swiss mice experimentally infected with different doses of A. costaricensis L3 and to determine whether infective doses are related to mortality. Thirty-two male Swiss mice were divided evenly into a non-infected control (NI-Con); low-dose infection (LD-Inf); medium-dose infection (MD-Inf) and high-dose infection (HD-Inf) groups infected with 0, 5, 15 and 30 A. costaricensis L3, respectively. Faecal samples were collected from each animal, starting at day 20 post infection. HD-Inf mice had greater faecal L1 shedding levels than LD-Inf mice, but not a significantly shortened survival. In conclusion, infective doses of A. costaricensis L3 affect L1 shedding levels without altering mortality in Swiss mice. |
| Databáze: | OpenAIRE |
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