Naltrexone as a treatment of self-injurious behavior - a case report

Autor:	H Griengl, A Sendera, K Dantendorfer
Rok vydání:	2001
Předmět:	medicine.medical_specialty Psychosis Narcotic antagonist social sciences medicine.disease Personality disorders Naltrexone Psychiatry and Mental health medicine Young adult Psychiatry Psychology Borderline personality disorder Endogenous opioid medicine.drug Psychopathology
Zdroj:	Acta Psychiatrica Scandinavica. 103:234-236
ISSN:	0001-690X
DOI:	10.1034/j.1600-0447.2001.00087.x
Popis:	Objective: Self-injurious behavior (SIB) is a phenomenon associated with different psychopathological conditions such as psychosis, mental retardation and especially severe personality disorders — mainly of the borderline subtype. It has been suggested that a blockade of the endogenous opioid system might lead to a reduction of the urge to SIB. Method: The case and successful treatment of SIB with naltrexone in a patient with borderline personality disorder and dysthymia is described. Results: After treatment trials with neuroleptics, antidepressants and valproate the patient was treated with naltrexone in a dosis of 50 mg/day and did not show SIB over a follow-up period of 32 weeks. Conclusion: Naltrexone could be effective in reducing SIB in patients with psychiatric disorders by blocking the positive reinforcement of SIB, which is reached by the release of endogenous opioides. Placebo-controlled studies of the efficacy of naltrexone in treating SIB should be undertaken.
Databáze:	OpenAIRE
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