Homeopathic Agents or Vitamins in Reducing Ecchymosis after Oculofacial Surgery
| Autor: | Jeremiah P. Tao, Timothy J. McCulley, Jill A. Foster, Vinay K. Aakalu, Rachel K. Sobel, Michael T. Yen, Suzanne K. Freitag, Edward J. Wladis |
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| Rok vydání: | 2022 |
| Předmět: |
Laser surgery
0303 health sciences medicine.medical_specialty business.industry medicine.medical_treatment Ecchymosis Perioperative Evidence-based medicine Controlled studies Placebo Surgery 03 medical and health sciences Ophthalmology 0302 clinical medicine 030221 ophthalmology & optometry medicine Level iii medicine.symptom business 030304 developmental biology Cohort study |
| Zdroj: | Ophthalmology. 129:220-226 |
| ISSN: | 0161-6420 |
| Popis: | Purpose To review the published literature to determine the efficacy and safety of homeopathic agents or vitamins in reducing ecchymosis after oculofacial surgery or laser surgery. Methods A literature search was conducted in the PubMed database initially in December 2019 and updated in March 2020 to identify all studies in the English language literature on the use of homeopathic agents or vitamins in oculofacial procedures, including laser surgery. The search yielded 124 citations, and 11 articles met all inclusion criteria for this assessment. A panel methodologist then assigned a level of evidence rating for each study. Eleven studies met inclusion criteria; 9 were rated level I, and 2 were rated level III. Results The agents studied in the articles identified included oral or topical Arnica montana (AM), oral Melilotus extract, topical vitamin K oxide, and topical AM combined with Rhododendron tomentosum. Metrics to describe ecchymosis varied. In 7 controlled studies, perioperative AM provided no or negligible benefit versus placebo. In 2 studies, vitamin K cream was equivalent to placebo. One study of oral Melilotus extract had less ecchymosis compared with controls in paranasal and eyelid ecchymosis at postoperative day (POD) 7, but not at PODs 1 and 4. A lone cohort study of combined topical AM and R. tomentosum lacked objective metrics and adequate controls. No serious side effects from administration of homeopathic agents or vitamins were identified. Conclusions The current literature does not support the use of AM, vitamin K oxide, R. tomentosum, or Melilotus extract for reducing ecchymosis after oculofacial surgery or pulsed dye laser surgery. |
| Databáze: | OpenAIRE |
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