Influence of Ulipristal Acetate Therapy on Uterine Fibroid-Related Symptoms and on Uterine and Fibroid Volumes and Vascularity Indices Assessed by Ultrasound
| Autor: | Lorenza Santi, Massimo Franchi, Paola Pomini, F. Presti, Fabiana Galeone, Ricciarda Raffaelli, Silvia Baggio |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
030219 obstetrics & reproductive medicine Radiological and Ultrasound Technology business.industry Uterine fibroids Ultrasound Urology medicine.disease Pulsatility index Symptomatic relief Response to treatment female genital diseases and pregnancy complications 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Vascularity chemistry Ulipristal acetate medicine.artery medicine Radiology Nuclear Medicine and imaging 030212 general & internal medicine medicine.symptom business Uterine artery |
| Zdroj: | Journal of Ultrasound in Medicine. 37:2215-2223 |
| ISSN: | 0278-4297 |
| Popis: | OBJECTIVES To investigate the modifications of uterine and fibroid volume, to study Doppler changes in uterine arteries and fibroid-supplying vessels, and to assess possible symptomatic relief after 3 months of treatment with ulipristal acetate. METHODS Forty-two premenopausal women with symptomatic fibroids were included in the study. They were evaluated clinically for the symptoms reported and underwent ultrasound examinations before starting treatment and after 3 months of therapy with ulipristal acetate. Transvaginal scanning was performed by the same sonographer, who measured the uterine volume and uterine artery pulsatility index and resistive index. Considering that some patients had more than 1 fibroid, the vascularization (supplying vessel pulsatility and resistive indices), locations, and sizes of a total of 73 fibroids were also recorded. RESULTS After 3 months of ulipristal acetate, patients had a significant improvement of all symptoms (P |
| Databáze: | OpenAIRE |
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