Carbonylative cross-coupling reaction of aryl iodides with alkylaluminums by palladium complex catalysis
| Autor: | Masaharu Kojima, Tomoyuki Yasunaga, Yoshiaki Wakita |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
chemistry.chemical_classification
Ketone Aryl Organic Chemistry chemistry.chemical_element Biochemistry Medicinal chemistry Coupling reaction Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Reagent Materials Chemistry Organic chemistry Physical and Theoretical Chemistry Carbonylation Carbon monoxide Palladium |
| Zdroj: | Journal of Organometallic Chemistry. 288:261-268 |
| ISSN: | 0022-328X |
| Popis: | Secondary and/or tertiary alcohols and unsymmetrical ketones have been obtained in moderate to good yields by the palladium-catalyzed (5 mol%) carbonylative coupling of aryl iodides with alkylaluminum compounds under very mild conditions (20–50°C, 1 atm of carbon monoxide). The type of the reaction product depended on the aluminum reagent employed. While the selective formation of secondary alcohols was observed in the reaction with i-Bu 3 Al, the use of Et 3 Al led to a mixture of a ketone and two alcoholic products. With Et 2 AlCl predominantly unsymmetrical ketones were produced. In all cases, formation of directly cross-coupled products was not observed. DME and benzene can be used as solvents, but THF is unsuitable. Nickel catalysts were found to be ineffective for this reaction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|