| Autor: |
Raphaël Robidas, Domenic P. Pace, Thanh Vinh Nguyen, Claude Y. Legault, Uyen P. N. Tran |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.26434/chemrxiv.12607529.v1 |
| Popis: |
Substituted pyrans and furans are core structures found in a wide variety of natural products and biologically-active compounds. Herein, we report a practical and mild catalytic method for the synthesis of substituted pyrans and furans using molecular iodine, a simple and inexpensive catalyst. The method described herein is performed in solvent-free conditions in ambient temperature and atmosphere, thus offering a facile and green alternative to currently available reaction protocols. A combination of experimental studies and high‐level DFT calculations revealed interesting mechanistic insights of this seemingly simple reaction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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