Investigation of TAGAP gene polymorphism (rs1738074) in Turkish pediatric celiac patients
| Autor: | Tülay Kiliçaslan Ayna, Aslı Özkızılcık Koçyiğit, İbrahim Pirim, Mustafa Soyöz, Melek Pehlivan, Burcu Çerçi, Maşallah Baran |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Genetics business.industry Turkish Biochemistry (medical) Clinical Biochemistry Biochemistry language.human_language 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Polymorphism (computer science) TAGAP gene language Medicine 030211 gastroenterology & hepatology business Molecular Biology |
| Zdroj: | Turkish Journal of Biochemistry. 46:293-298 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2020-0419 |
| Popis: | Objectives There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the TAGAP gene; however, there has been no study on Turkish pediatric patients. We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients. Methods Totally, 127 pediatric CD patients and 100 healthy children were included. We determined the polymorphism by the allele-specific polymerase chain reaction method. We used IBM SPSS Statistics version 25.0 and Arlequin 3.5.2 for the statistical analyses. The authors have no conflict of interest. Results It was determined that 72% (n=154) of only CD patients had C allele, whereas 28% (n=60) had T allele. Of the patients with celiac and T1DM, 42.5% (n=17) and 57.5% (n=23) had T and C alleles, respectively. Of the individuals in control group, 67% (n=134) had C allele, whereas 33% (n=66) had T allele. Conclusions There was no significant difference in the genotype and allele frequencies between the patient and control groups (p>0.05). There was no significant association between the disease risk and the polymorphism in our study group. |
| Databáze: | OpenAIRE |
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