Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families
| Autor: | Kerry E Broe, Yanhua Zhou, Mary L. Bouxsein, Douglas P. Kiel, Serkalem Demissie, Darlene Lu, David Karasik, L. Adrienne Cupples |
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| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Bone mineral education.field_of_study Bone density medicine.diagnostic_test Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism Anatomy Biology Heritability 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Framingham Heart Study medicine Orthopedics and Sports Medicine Tibia Quantitative computed tomography education Genetic association |
| Zdroj: | Journal of Bone and Mineral Research. 32:106-114 |
| ISSN: | 0884-0431 |
| Popis: | High-resolution peripheral quantitative computed tomography (HR-pQCT) measures bone microarchitecture and volumetric bone mineral density (vBMD), important risk factors for osteoporotic fractures. We estimated the heritability (h2 ) of bone microstructure indices and vBMD, measured by HR-pQCT, and genetic correlations (ρG ) among them and between them and regional aBMD measured by dual-energy X-ray absorptiometry (DXA), in adult relatives from the Framingham Heart Study. Cortical (Ct) and trabecular (Tb) traits were measured at the distal radius and tibia in up to 1047 participants, and ultradistal radius (UD) aBMD was obtained by DXA. Heritability estimates, adjusted for age, sex, and estrogenic status (in women), ranged from 19.3% (trabecular number) to 82.8% (p |
| Databáze: | OpenAIRE |
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