Does the Solid-Phase Synthesis of a Tetrapeptide Represent a Challenge at the Onset of the XXI Century? The Case of Cyclo [(3R)-3-hydroxydecanoyl-l-seryl-(3R)-3-hydroxydecanoyl-l-seryl]

Autor:	Ernest Giralt, Fernando Albericio, Esther Zurita, Marc Martinell, Meritxell Teixidó, Marta Vilaseca, Roger Prades, Josep Maria Caba
Rok vydání:	2007
Předmět:	Biological studies biology Tetrapeptide Stereochemistry Chemistry Pharmacology toxicology Bioengineering biology.organism_classification Biochemistry Combinatorial chemistry Analytical Chemistry Solid-phase synthesis Drug Discovery Serratia marcescens Molecular Medicine Serratamolide
Zdroj:	International Journal of Peptide Research and Therapeutics. 13:313-327
ISSN:	1573-3904 1573-3149
Popis:	At the beginning of the XXI century, 43 years after the description of the first solid-phase synthesis of a tetrapeptide by Bruce Merrifield, the synthesis of a tetrapeptide may still represent a synthetic challenge. This is the case of serratamolide, a cyclic tetradepsipeptide originally found in a culture of Serratia marcescens, which exhibits interesting properties as a chemotherapeutic agent. Here we explore several methodologies for the synthesis of serratamolide in order to find a strategy that allows its preparation for further biological studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e061294bfd2b588b302f658fd732535e https://doi.org/10.1007/s10989-007-9086-z Zobrazit plný text záznamu Full text from SpringerLink