Electrocatalytic and chemical methods in MHIRC reactions: the first example of the multicomponent assembly of medicinally relevant spirocyclopropylbarbiturates from three different molecules

Autor:	Michail N. Elinson, Evgeniya O. Dorofeeva, Gennady I. Nikishin, Tatiana A. Zaimovskaya, Nikita O. Stepanov, Anatolii N. Vereshchagin
Rok vydání:	2013
Předmět:	Electrolysis Organic Chemistry Alcohol Electrocatalyst Biochemistry Combinatorial chemistry law.invention chemistry.chemical_compound Sodium bromide chemistry law Yield (chemistry) Drug Discovery Halogen Molecule Malononitrile
Zdroj:	Tetrahedron. 69:1945-1952
ISSN:	0040-4020
DOI:	10.1016/j.tet.2012.12.029
Popis:	Electrolysis of aldehydes, barbituric acids, and malononitrile in alcohol in an undivided cell in the presence of sodium bromide results in efficient MHIRC formation of the corresponding spirocyclopropylbarbiturates in 50–65% substance yield. The electrocatalytic reaction smoothly proceeds under neutral and mild conditions with aromatic aldehydes bearing both electron-donating and electron-withdrawing groups. The implication of electrocatalysis in MHIRC reaction is an efficient approach to medicinally relevant spirocyclopropylbarbiturates avoiding the inconvenient direct use of molecular halogen or halogenated substrates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e05f311e3c041cbce1502ced3f9a12b1 https://doi.org/10.1016/j.tet.2012.12.029 Zobrazit plný text záznamu Full Text from ScienceDirect