Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes: Synthesis, electrochemistry and antiplasmodial evaluation
| Autor: | Carmen de Kock, Peter Malatji, Gregory S. Smith, Pete Smith, Kelly Chibale, Alan T. Hutton, Muneebah Adams |
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| Rok vydání: | 2013 |
| Předmět: |
inorganic chemicals
Stereochemistry Bioorganometallic chemistry Organic Chemistry chemistry.chemical_element Biological activity Cleavage (embryo) Electrochemistry Biochemistry Medicinal chemistry Inorganic Chemistry chemistry.chemical_compound chemistry Materials Chemistry Ferrocenyl group Physical and Theoretical Chemistry Cyclic voltammetry Semicarbazone Palladium |
| Zdroj: | Journal of Organometallic Chemistry. 739:15-20 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2013.04.017 |
| Popis: | Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes ( 3 – 5 ) were prepared through the cleavage of a chlorido-bridged palladium ferrocenylthiosemicarbazone intermediate ( 2 ) using various P-donor ligands. These compounds were screened for antiplasmodial activity against chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) Plasmodium falciparum strains, exhibiting biological activity in the low micromolar range. The compounds generally display well-resolved electrochemically reversible one-electron transfer processes for the ferrocenyl group. The half-wave potential for the Fe(II)/Fe(III) couple is electronically influenced by the type of P-donor group through the palladium(II) centre. |
| Databáze: | OpenAIRE |
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