Epstein–Barr-virus-infected Plasma Cells Infiltrating Plasma Cell Mucositis of the Oral Cavity and Larynx
| Autor: | Haruna Yabe, Kazutoshi Nakaoka, Yumi Ito, Go Arai, Yoshiki Hamada, Kenichi Kumagai, Takanori Eguchi, Koichiro Sato |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Larynx
Pathology medicine.medical_specialty business.industry Plasma cell medicine.disease_cause Immunoglobulin light chain medicine.disease Epstein–Barr virus Virus Pathology and Forensic Medicine medicine.anatomical_structure Otorhinolaryngology medicine Mucositis Surgery Oral Surgery business Glucocorticoid B cell medicine.drug |
| Zdroj: | Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 34:480-484 |
| ISSN: | 2212-5558 |
| DOI: | 10.1016/j.ajoms.2021.11.005 |
| Popis: | Epstein–Barr virus (EBV)-infected plasma cell mucositis (PCM) presenting as concurrent oral and laryngeal lesions. A 77-year-old woman presented with gingival swelling, soreness, a dry cough, and hoarseness. Incisional biopsies of the gingiva and larynx were performed. Histological examination revealed PCM. Dramatic improvement was observed after systemic glucocorticoid administration. The serum free light chain levels were correlated with disease activity. EBV infection boosts local B cell lymphoproliferation. Various immunosuppressive states trigger direct EBV-mediated activation of B cell lymphoproliferation by suppressing the functions of T cells. This case suggests a possible pathogenetic mechanism of plasma cell lymphoproliferation of the PCM. |
| Databáze: | OpenAIRE |
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