| Autor: |
Liao-Yun Zhang, Wen Xie, Rui-Xia Xue, H.C. Xing, Song Yang, Qi Wang, Jun Cheng, Jiang Guo |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
World Chinese Journal of Digestology. 17:1260 |
| ISSN: |
2219-2859 |
| Popis: |
AIM: To investigate the resistance profiles of chronic hepatitis B patients with entecavir (ETV) refractory treatment. METHODS: Twenty serum samples of patients who failed treatment with ETV were assigned into non-complete virological group and virological breakthrough group in accordance with response action. Direct sequencing of PCR products was used to determine ETV resistance. NCBI HBV genotyping tool was used to identify HBV genotype. RESULTS: ETV resistance was detected from 11 out of 20 ETV-refractory patients, all of which was in virological breakthrough group, and rtM204V + rtL180M + rtT184L was common in Chinese ETV resistance patients. There was remarkably statistical difference between the two groups (P = 0.0022). Three in 6 patients with genotype B were detected to have ETV resistance, meanwhile 11 in 14 with genotype C. There was no statistical difference in resistance among genotype B and C patients. CONCLUSION: rtM204V + rtL180M + rtT184L mutations are common in genotype B and C ETV resistance patients. Patients with virological breakthrough experienced more ETV resistance than non-complete virological group. There is no statistical difference in resistance between genotype B and C patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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