Role of Transarterial Chemoembolization (TACE) in Down Staging of Hepatocellular Carcinoma (HCC) before Liver Transplantation
| Autor: | Haytham Mohamed Nasser, Mohamed E. Aboelmaaty, Abdallah Lutfy Farouk Ahmed, Iman F. Montasser |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Cirrhosis business.industry Hepatitis C virus medicine.medical_treatment Down staging Milan criteria Liver transplantation medicine.disease_cause medicine.disease Gastroenterology digestive system diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Hepatocellular carcinoma Internal medicine medicine Etiology 030211 gastroenterology & hepatology business Living donor liver transplantation |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 72:5578-5583 |
| ISSN: | 2090-7125 |
| DOI: | 10.21608/ejhm.2018.11513 |
| Popis: | Background: liver transplantation (LT) has emerged as the optimal treatment for cirrhotic patients with Hepatocellular carcinoma (HCC) because it cures both tumor and underlying cirrhosis. HCC could be downstaged or controlled by various anticancer therapies, which might bring them chance of undergoing a curative treatment such as LT. Aim of the Work: it was to evaluate the outcomes of HCC downstaged patients using transarterial hepatic chemoembolization (TACE) therapy to allow eligibility for liver transplantation. Patients and Methods: the study included all the cirrhotic patients who underwent TACE for downstaging of HCC to become eligible for liver transplantation at the period from 2008 to 2017 in Ain Shams Specialized Hospital. Al the patients underwent TACE to meet the Milan criteria for liver transplantation. Results: the etiology of cirrhosis and HCC in our patients was primarily Hepatitis C virus which is endemic in our country. All the cases were not eligible for liver transplantation because they were out of Milan criteria, therefore all the cases underwent TACE for downstaging of the tumor to be within the Milan criteria to become fit for liver transplantation. After undergoing TACE for downstaging, Patients underwent living donor liver transplantation, then they were followed up for detection of recurrence on the transplanted liver. Four of the twenty seven patients had recurrent HCC (14.8 %). Conclusion: successful down-staging of HCC by TACE can be achieved in the majority of carefully selected patients and is associated with excellent posttransplantation outcome. |
| Databáze: | OpenAIRE |
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