Formulation and Evaluation of Mouth Dissolving Tablet of Benazepril Hydrochloride
| Autor: | Poonam S. Sable, Deepak A. Kulkarni, Geeta P. Darekar, Vani H. Bhargava |
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| Rok vydání: | 2021 |
| Předmět: |
Benazepril Hydrochloride
Chromatography Chemistry 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Bioavailability 03 medical and health sciences 0302 clinical medicine Drug release Pharmacology (medical) 0210 nano-technology Pharmacology Toxicology and Pharmaceutics (miscellaneous) Dissolution |
| Zdroj: | Research Journal of Pharmacy and Technology. :3161-3166 |
| ISSN: | 0974-360X 0974-3618 |
| Popis: | Antihypertensive drugs are expected to give quicker action with better bioavailability. In the present study, mouth dissolving tablets of Benazepril Hydrochloride were formulated by using direct compression technique employing combination of a superdisintegrants to achieve rapid disintegration of the tablets in oral cavity Croscarmellose sodium, sodium starch glycolate and crospovidone were used as superdisintegrant to prepare six batches of mouth dissolving tablets out of which tablets prepared from crospovidone showed best results. Drug and physical mixture was characterized by FTIR for compatibility study. Optimization technique was employed to predict the best formulation of all the combinations prepared. Prepared formulations were optimized and evaluated for wetting time, dispersion time and different quality parameters. Optimized formulation was compared with marketed formulation for in vitro drug release and it was found that mouth dissolving tablet shows efficient drug release. |
| Databáze: | OpenAIRE |
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