Synthesis of 6,8-dichloroquinolones utilizing new method and evaluation of their antibacterial activities

Autor:	Hui Yuan Guo, Yun Xu Yang
Rok vydání:	2007
Předmět:	biology Chemistry Stereochemistry Pseudomonas Tetrachlorophthalic anhydride General Chemistry biology.organism_classification medicine.disease_cause Combinatorial chemistry In vitro Carbonyl chloride Ciprofloxacin Escherichia medicine Staphylococcus Norfloxacin medicine.drug
Zdroj:	Chinese Chemical Letters. 18:1479-1482
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2007.10.012
Popis:	Several 6,8-dichloroquinolone analogues were synthesized from the key intermediate compound of 2,3,4,5-tetrachlorobenzene carbonyl chloride, which was obtained from the starting material of tetrachlorophthalic anhydride. Their in vitro antibacterial activities were evaluated. As a result of this study, compounds 21c and 21d were twofold more potent than ciprofloxacin (CPFX) and norfloxacin (NFLX) against Staphylococcus aureus-9, and with the same potent as CPFX and NFLX while against Escherichia coli-2, but were less potent than references in against Pseudomonas aeruginosa-17.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e03c2112dcc5fa2cedc98a0cd8a3dc4d https://doi.org/10.1016/j.cclet.2007.10.012 Zobrazit plný text záznamu Full Text from ScienceDirect