PATH-06. Molecular subgrouping of medulloblastoma via low-depth whole genome bisulfite sequencing

Autor:	Dean Thompson, Jemma Castle, Debbie Hicks, Ed Schwalbe, Steve Clifford
Rok vydání:	2022
Předmět:	Cancer Research Oncology Neurology (clinical)
Zdroj:	Neuro-Oncology. 24:i159-i159
ISSN:	1523-5866 1522-8517
Popis:	INTRODUCTION: International consensus recognises four molecular subgroups of medulloblastoma, each with distinct molecular features and clinical outcomes. Assigning molecular subgroup is typically achieved via the Illumina DNA methylation microarray. Given the rapidly-expanding WGS capacity in healthcare institutions, there is an unmet need to develop platform-independent, sequence-based subgrouping assays. Whole genome bisulfite sequencing (WGBS) enables the assessment of genome-wide methylation status at single-base resolution. To date, its routine application for subgroup assignment has been limited, due to high economic cost and sample input requirements. Currently, no optimised pipeline exists that is tailored to handle samples sequenced at low-pass (i.e.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e0398ea5896d01e1a5cdc67d730b8673 https://doi.org/10.1093/neuonc/noac079.590 Zobrazit plný text záznamu