RyRs Coupling Causes a Calcium Leak in Cardiac Cell
| Autor: | A. M. Ryvkin, Nikita Markov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
inorganic chemicals
0301 basic medicine 030103 biophysics Diffusion problem Ryanodine receptor Endoplasmic reticulum Allosteric regulation chemistry.chemical_element Calcium musculoskeletal system Cardiac cell Dyadic space Calcium sparks 03 medical and health sciences chemistry cardiovascular system Biophysics tissues |
| Zdroj: | CinC |
| ISSN: | 2325-887X |
| Popis: | Here we introduce results of a mathematical modeling of calcium sparks in cardiac cells. We developed a model of the calcium release unit which includes a single sarcoplasmic reticulum (SR) lumen, a regular 9×9 cluster of RyRs and a dyadic space. 2D diffusion problem of Ca2+ ions across the dyadic space was solved thereby we reproduced Calcium-fnduced-Calcium-Release (CICR) effect and domino-like RyRs activation in the cluster. We take into account allosteric and Ca2+-induced coupling between RyRs. We show, that coupling between RyRs leads to the stability of Ca2+ sparks in amplitude and frequency. However, a sudden stop of spontaneous Ca2+ releases can be a result of strong allosteric coupling between RyRs. |
| Databáze: | OpenAIRE |
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