Calcitonin pump improves nerve regeneration after transection injury and repair
| Autor: | Hani S. Matloub, Robert J. Havlik, Michael Agresti, Lin-Ling Zhang, James R. Sanger, John A. Davis, John A. LoGiudice, Ji-Geng Yan |
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| Rok vydání: | 2014 |
| Předmět: |
Sciatic Neuropathy
Physiology business.industry Nerve fiber Nerve injury Compound muscle action potential Cellular and Molecular Neuroscience medicine.anatomical_structure Calcitonin Physiology (medical) Anesthesia Peripheral nerve injury Medicine Neurology (clinical) Sciatic nerve medicine.symptom business Epineurial repair |
| Zdroj: | Muscle & Nerve. 51:229-234 |
| ISSN: | 0148-639X |
| DOI: | 10.1002/mus.24281 |
| Popis: | Introduction: After nerve injury, excessive calcium impedes nerve regeneration. We previously showed that calcitonin improved nerve regeneration in crush injury. We aimed to validate the direct effect of calcitonin on transected and repaired nerve. Methods: Two rat groups (n = 8) underwent sciatic nerve transection followed by direct repair. In the calcitonin group, a calcitonin-filled mini-osmotic pump was implanted subcutaneously, with a catheter parallel to the repaired nerve. The control group underwent repair only, without a pump. Evaluation and comparison between the groups included: (1) compound muscle action potential recording of the extensor digitorum longus (EDL) muscle; (2) tetanic muscle force test of EDL; (3) nerve calcium concentration; and (4) nerve fiber count and calcified spot count. Results: The calcitonin pump group showed superior recovery. Conclusions: Calcitonin affects injured and repaired peripheral nerve directly. The calcitonin-filled mini-osmotic pump improved nerve functional recovery by accelerating calcium absorption from the repaired nerve. This finding has potential clinical applications. Muscle Nerve 51: 229–234, 2015 |
| Databáze: | OpenAIRE |
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