ChemInform Abstract: Potent Inhibitors of the MAP Kinase p38

Autor:	Peter H. Schafer, Kenneth C. Rupert, Scott A. Wadsworth, John Siekierka, Ignatius J. Turchi, John H. Dodd, Druie Cavender, Henry James Robert
Rok vydání:	2010
Předmět:	biology Chemistry p38 mitogen-activated protein kinases Rheumatoid arthritis Mitogen-activated protein kinase medicine Cancer research biology.protein General Medicine medicine.disease Inflammatory bowel disease Proinflammatory cytokine
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
Popis:	The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e00bdf559f283966740b486a1f8ffc0b https://doi.org/10.1002/chin.199911166 Zobrazit plný text záznamu Plný text