Serum Heat Shock Protein 60 in Acute Heart Failure: A New Biomarker?
| Autor: | Julio Núñez, Marifina Chillet, Gema Miñana, Vicente Bodi, Fabian Chaustre, Àngel Llàcer, Francisco J. Chorro, Eduardo Núñez, Patricia Palau, Maria J. Forteza, David Navarro, Juan Sanchis, Clara Bonanad |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
business.industry Proportional hazards model Incidence (epidemiology) Hazard ratio Emergency Nursing medicine.disease Confidence interval Surgery Interquartile range Heat shock protein Internal medicine Heart failure Emergency Medicine Cardiology medicine Biomarker (medicine) Cardiology and Cardiovascular Medicine business |
| Zdroj: | Congestive Heart Failure. 19:6-10 |
| ISSN: | 1527-5299 |
| DOI: | 10.1111/j.1751-7133.2012.00299.x |
| Popis: | Heat shock protein 60 (HSP60) is a mitochondrial protein constitutively expressed in the majority of cells, and its expression is up-regulated by a variety of stressors. In heart failure, HSP60 is released from cardiomyocytes. The authors speculate that increased serum HSP60 (sHSP60) may be related to the severity of heart failure. This investigation sought to assess the association between sHSP60 and the composite end point of death ⁄ readmission in patients with acute heart failure (AHF). A total of 132 consecutive patients were admitted for AHF. The independent association between sHSP60 and the end point was assessed with Cox regression. During a median follow-up of 7 months (interquartile range, 3–14), 35 (26.5%) deaths, 40 (30.3%) readmissions, and 65 (49.2%) deaths ⁄ readmission were identified. Patients who exhibited the outcome showed higher median sHSP60 values (6.15 ng ⁄ mL [8.49] vs 4.71 ng ⁄ mL [7.55] P=.010). A monotonic increase in the incidence of the composite end point was observed when moving from lower to higher tertile (4.74, 4.76, and 6.98 per 10 patients-years of follow-up, P for trend |
| Databáze: | OpenAIRE |
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