Preparation of superoxide dismutase entrapped in ceramide-containing liposomes for oral administration

Autor:	E. Postaire, Monique Roch-Arveiller, C. Regnault, H. Fessi, G. Hazebroucq, C. Benoist
Rok vydání:	1996
Předmět:	Ceramide Liposome Chromatography biology Chemistry technology industry and agriculture Phospholipid Pharmaceutical Science Dosage form Superoxide dismutase chemistry.chemical_compound Oral administration Dipalmitoylphosphatidylcholine biology.protein Drug carrier
Zdroj:	International Journal of Pharmaceutics. 132:263-266
ISSN:	0378-5173
Popis:	Ceramides and distearoylphosphatidylcholine (DSPC) were incorporated in various liposomes preparations in comparison with dipalmitoylphosphatidylcholine alone. Preparations were introduced in an ‘Artificial Stomach-Duodenum’ model to improve their stability. Better results were observed for DSPC and ceramide-containing liposomes. Entrapment of CuZn Superoxide dismutase (SOD) in liposomes have been carried out for oral administration. The efficiency of entrapment of SOD was 35.4% for liposomes without ceramides, and from 24.3% to 46.1% for ceramide-containing liposomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e0028b87079a57126d70c0e74ab859b6 https://doi.org/10.1016/0378-5173(95)04235-0 Zobrazit plný text záznamu Full Text from ScienceDirect