Effect of administration of phenylephrine immediately after low dose insemination on pregnancy rates in mares
| Autor: | James Shewmaker, Anne Josson-Schramme, M. D. Whitacre, Renan Sper, C. Nick Buchanan, T.M. Beachler, C. Scott Bailey |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
endocrine system
medicine.medical_specialty animal diseases media_common.quotation_subject medicine.medical_treatment Semen Insemination Andrology biology.animal Medicine Ovulation Phenylephrine reproductive and urinary physiology media_common Gynecology Pregnancy biology urogenital system business.industry Pony Artificial insemination Horse medicine.disease sense organs business medicine.drug |
| Zdroj: | Open Journal of Obstetrics and Gynecology. :722-726 |
| ISSN: | 2160-8806 2160-8792 |
| DOI: | 10.4236/ojog.2013.310133 |
| Popis: | There is considerable pressure on equine veterinarians to achieve good pregnancy rates with very small doses of semen. Phenylephrine administration in the rabbit increased numbers of oviductal, uterine, and cervical sperm, myometrial contractions, and fertilized ova after low dose insemination. The use of phenylephrine to enhance uterine contractility and fertility has not been investigated in the mare. Thus, the objective of this study was to determine if phenylephrine administration would result in clinically acceptable pregnancy rates in mares bred by low dose insemination. The hypothesis (Ha) was that pregnancy rates would be significantly higher in mares receiving phenylephrine compared to saline controls. Six pony mares and eight horse mares were enrolled in this study. Mares were inseminated within 24 hours of ovulation with 30 million progressively motile spermatozoa from a single fertile stallion. Immediately following insemination, mares were administered either phenylephrine (0.06 mg/kg) or 1mL of saline via IV injection. Pregnancy status was determined 14 days following ovulation via transrectal ultrasonography. Pregnancy rates in phenylephrine treated mares were 44% (4/9) while 22% (2/9) in saline-treated mares (P > 0.05). |
| Databáze: | OpenAIRE |
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