Amycolasporins and Dibenzoyls from Lichen-Associated Amycolatopsis hippodromi and Their Antibacterial and Anti-inflammatory Activities
| Autor: | Yi Jiang, Bixuan Cao, Peipei Guan, Bin Lin, Ying Jin, Aobulikasimu Nuerbiye, Xueshi Huang, Yu Mu, Li Han, Zengguang Zhang, Chengbin Liu |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
biology Chemistry medicine.drug_class Organic Chemistry Pharmaceutical Science Bacillus subtilis Amycolatopsis hippodromi medicine.disease_cause biology.organism_classification Anti-inflammatory Analytical Chemistry Microbiology Nitric oxide synthase Complementary and alternative medicine Staphylococcus aureus Mic values Drug Discovery medicine biology.protein Molecular Medicine Fermentation broth Escherichia coli |
| Zdroj: | Journal of Natural Products. 83:3545-3553 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.0c00547 |
| Popis: | Eleven metabolites, six echinosporins (1-6), four dibenzoyls (7-10), and an aromatic compound (11), were isolated from the fermentation broth of lichen-associated Amycolatopsis hippodromi. The structures of the new compounds (1-5, 8-11) were elucidated by comprehensive spectroscopic analysis including data from experimental and calculated ECD spectra. Amycolasporins A-C (1-3) demonstrated antibacterial activities against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli with MIC values of 25 or 100 μg/mL. Amycolasporin C (3) and the known dibenzoyl (7) attenuated the production of NO due to the suppression of the expression of nitric oxide synthase (iNOS) in LPS-induced RAW 264.7 cells in a dose-dependent manner. |
| Databáze: | OpenAIRE |
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