¿Es la atrofia del hipocampo en la enfermedad de Parkinson un predictor de demencia?
| Autor: | Carme Junqué Plaja, Naroa Ibarretxe-Bilbao |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Magnetic resonance imaging General Medicine Disease Hippocampal formation medicine.disease Gastroenterology Hippocampal atrophy Atrophy Internal medicine mental disorders medicine Dementia Neuropsychological assessment Psychology Psychiatry Cognitive impairment |
| Zdroj: | Alzheimer. Realidades e investigación en demencia. :5-11 |
| ISSN: | 2013-6889 1137-1242 |
| Popis: | Background and objective: Parkinson’s disease (PD) is a neurodegenerative disorder frequently associated to dementia. The presence of visual hallucinations (VH) is a clinical predictor of dementia in PD. In other neurodegenerative diseases such as Alzheimer’s disease (AD) magnetic resonance imaging (MRI) studies have shown that the atrophy of the hippocampus is a reliable predictor of evolution to dementia in subjects with amnesic mild cognitive impairment. The objective of the present study is to investigate the atrophy of the hippocampus as a predictor of dementia in PD. Patients and method: 11 PD patients with VH and 12 patients without VH were longitudinally assessed after a follow-up period of 30 ± 5.7 months. Patients underwent a structural MRI and a neuropsychological assessment both at the entry of the study and at follow-up. Individual and group analyses to evaluate the hippocampal gray matter loss were carried out by means of region of interest analysis (ROI) from voxel-based morphometry (VBM) of the SPM5 program. Results: at base-line none of the patients met criteria for dementia. At follow-up 73% of the patients with VH met criteria for dementia whereas none of the patient without VM met criteria for it. In the PD with VH group the hippocampal atrophy evolved from an anterior to antero-posterior predominance. The individual analyses showed that 64% of patients with VH presented hippocampal atrophy, and all of those who presented atrophy developed dementia. Conclusion: the hippocampal atrophy in PD is a marker of evolution to dementia and can explain the memory decline observed in these patients. |
| Databáze: | OpenAIRE |
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