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The bark of Kigelia africana Lam. (Benth.) as powder or infusion is used in ethnomedicine for the treatment of ulcers, or applied in treatment of pneumonia and malaria. Hence the aqueous and ethanolic extracts of Kigelia africana were investigated for antipyretic activity in albino rabbits. Pyrexia was induced by Escherichia coli, at a dose of 106cfu /ml. Escherichia coli was injected intravenously via the marginal ear vein, at a dose of 1ml/ 5kg body weight of the rabbits. An hour later the extracts, aqueous and ethanolic (500mg/kg & 1000mg/kg respectively) were given via the oral route. The ethanolic extract showed marked antipyretic activity based on the reduction of pyrogen-induced fever in rabbits (P Keywords : Kigelia africana ; Antipyretic activity; E. coli Journal of Pharmacy and Bioresources Vol. 4 (1) 2007: pp. 20-24 |
