Study of membranotropic and antioxidant activity of flavonoids and their complexes with ferric iron

Autor:	S. M. Kuznetsova, Eugeny N. Muzafarov, Yu. A. Kim, Elena A. Yagolnik, I. B. Klenina, Yu. S. Tarahovsky
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Liposome Antioxidant medicine.medical_treatment Flavonoid Biophysics Catechin Lipid peroxidation chemistry.chemical_compound chemistry Lipophilicity medicine Organic chemistry Taxifolin heterocyclic compounds Quercetin Nuclear chemistry
Zdroj:	Biophysics. 58:646-652
ISSN:	1555-6654 0006-3509
DOI:	10.1134/s0006350913050187
Popis:	We studied the interaction with liposomes and the antioxidant activity of flavonoid (quercetin, catechin, taxifolin) complexes with iron(III). It was found that the lipophilicity of complexes depends on an iron:flavonoid ratio and grows at a ratio of 1 to 1, while complexes in a 2: 1 ratio were the most effective to slow down the lipid peroxidation and restore radical 2,2-diphenyl-1-picrylhydrazyl. Thus, the stoichiometry of complexes formed in aqueous solution, may differ from the stoichiometry of complexes that most effectively protect membranes from peroxidation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dfd9e1fd44dabf55c860ff5b404026c8 https://doi.org/10.1134/s0006350913050187 Zobrazit plný text záznamu Full text from SpringerLink