Alginate Nonwoven-Sponge Composite Scaffold for Rotator Cuff Tendon Repair
| Autor: | Jong Pil Yoon, Ga Young Park, Jin Hyun Choi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Materials science Polymers and Plastics biology General Chemical Engineering Regeneration (biology) Biomaterial 02 engineering and technology General Chemistry musculoskeletal system 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences 0104 chemical sciences Tendon Sponge medicine.anatomical_structure Ultimate tensile strength medicine Rotator cuff Composite scaffold 0210 nano-technology Biomedical engineering |
| Zdroj: | Fibers and Polymers. 21:1879-1887 |
| ISSN: | 1875-0052 1229-9197 |
| DOI: | 10.1007/s12221-020-9771-5 |
| Popis: | Growth factor-mediated healing of rotator cuff tendon requires to develop a clinically applicable biomaterial playing roles of mechanical support and growth factor release in vivo. In this study, the alginate (AG) nonwoven-sponge composite scaffold (AGNWSP) was fabricated through the formation of an AG sponge layer on the AG nonwoven scaffold (AGNW) surface, and rotator cuff repair with the AG-based scaffolds containing transforming growth factor-beta 1 (TGF-β1) was investigated with a rabbit model. AGNWSP had higher tensile strength, lower bioabsorbability, and higher sustained TGF-β1 release capacity than AGNW, which were highly correlated with tendon regeneration. AGNW and AGNWSP were fixed to the ruptured tendon-to-bone sites, and fresh solutions of TGF-β1 were injected into the scaffolds. When AGNWSP was applied, the repaired supraspinatus tendon had higher ultimate failure load and stress. In addition, well-organized collagen fibers and fibrocartilages were observed at the tendon-to-bone interface in this case. It is suggested that high degree of ruptured rotator cuff healing could be achieved with AGNWSP in combination with TGF-β1. |
| Databáze: | OpenAIRE |
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