An Efficient, Commercially Viable, and Safe Process for Preparation of Losartan Potassium, an Angiotensin II Receptor Antagonist

Autor:	Raghu Babu Korupolu, Aminul Islam, Suri Babu Madasu, Ch Koteswaramma, Paul Douglas Sanasi, N. A. Vekariya
Rok vydání:	2012
Předmět:	Losartan Potassium medicine.drug_class Chemistry Organic Chemistry medicine Angiotensin II receptor antagonist Physical and Theoretical Chemistry Pharmacology Antihypertensive drug
Zdroj:	Organic Process Research & Development. 16:2025-2030
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op300179u
Popis:	An efficient, commercially viable and safe process for the preparation of losartan potassium, an antihypertensive drug substance, with an overall yield of 55.5% and ∼99.9% purity (including five chemical reactions and two recrystallizations) and meeting all other regulatory requirements is described. Formation and control of all the possible impurities are also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dfcb8aac493f873b422b0aff54c48ff8 https://doi.org/10.1021/op300179u Zobrazit plný text záznamu