Application of an Original process for Obtaining Colloidal Dispersions of Some Coating Polymers. Preparation, Characterization, Industrial Scale-Up
| Autor: | Hatem Fessi, Francis Puisieux, J.P. Devissaguet, O. Thioune, A. de Labouret |
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| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Aqueous solution Materials science Organic Chemistry Pharmaceutical Science Polymer engineering.material Characterization (materials science) Solvent Colloid chemistry Chemical engineering Coating Pulmonary surfactant Scientific method Drug Discovery Polymer chemistry engineering |
| Zdroj: | Drug Development and Industrial Pharmacy. 21:229-241 |
| ISSN: | 1520-5762 0363-9045 |
| Popis: | An original process for obtaining colloidal dispersions were used to prepare pseudolatex of coating polymers (Eudragit E 100 and Eudragit S 100). The method consists in introducing under magnetic stirring a solution of the polymers in a water-miscible solvent into an aqueous solution containing surfactant. In these conditions, polymers precipitate spontaneously in nanospheres. Investigations of some manufacturing parameters (initial polymer concentration, nature and concentration of surfactant) have allowed development of formulae for a semi-industrial seal-up. Characteristics of dispersions were also determined. |
| Databáze: | OpenAIRE |
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