Reactions of Electron-Rich Olefins with Proton-Active Compounds

Autor:	Rudolf Dr Merten, Jurgen Hocker
Rok vydání:	1972
Předmět:	chemistry.chemical_classification Proton Double bond food and beverages General Medicine General Chemistry Electron Cleavage (embryo) Catalysis chemistry.chemical_compound chemistry Nucleophile β elimination Organic chemistry Thiamine Tetrahydrofolic acid
Zdroj:	Angewandte Chemie International Edition in English. 11:964-973
ISSN:	1521-3773 0570-0833
DOI:	10.1002/anie.197209641
Popis:	Proton-active substances react with certain electron-rich olefins with cleavage of the central CC double bond to give compounds that can be formally regarded as insertion products of nucleophilic carbenes. If they satisfy certain structural conditions, they isomerize with β elimination to give open-chain compounds. Both CH-acidic compounds and compounds containing NH or OH groups can undergo this reaction. The mechanisms are discussed, and the importance of the intermediate products to biochemistry (thiamine, tetrahydrofolic acid) is indicated.
Databáze:	OpenAIRE
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