Two Transition Metal Complexes: Magnetic Properties and Treatment Effect via Focused High-Intensity Ultrasound on Alzheimer’s Disease
| Autor: | Chang-Lu Huo, Ting Yu, Ying-Rui Zhang, Ying-Li Zhang, Ling-Ling Liu, Cai-Ying Pei |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics Ligand General Chemical Engineering Metal ions in aqueous solution Organic Chemistry Nanochemistry 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Crystallography chemistry.chemical_compound Transition metal chemistry Isothiocyanate Materials Chemistry Propidium iodide Carboxylate 0210 nano-technology |
| Zdroj: | Macromolecular Research. 29:376-382 |
| ISSN: | 2092-7673 1598-5032 |
| Popis: | Two novel coordination polymers (where Cu for the complex 1 and the Co for the complex 2) with distinct transition metal ions containing 4-(3,5-dicarboxylphenyl)-2-methylpyridine (H2L), the pyridyl-dicarboxylic acid ligand, have been produced under the solvothermal reaction conditions, and the two compounds’ performances and architectures were also characterized. The chemical formulae determined of two complexes are respectively [Cu(L)(H2O)]·H2O (1) and [Co3(L)2Cl2(H2O)2]·2H2O (2). Complex 1 exhibits a 2D network with a (3,6)-connected kgd topology based on the dinuclear [Cu2O2] units. In complex 2, the linear trinuclear [Co3(μ-Ocarboxylate)2(COO)2Cl2] units with mixed carboxylate and μ-Cl triple bridges are cross-linked by the L ligands into a 3D framework with a (3,6)-connected rtl topology. The complexes’ magnetic performances reflected that between consecutive metal ions, there exists the antiferromagnetic coupling. Their treatment activities on Alzheimer’s disease (AD) via focused high-intensity ultrasound were evaluated. Firstly, the Annexin V-fluorescein isothiocyanate/propidium iodide staining was implemented for the assessment of the apoptotic neurons percentage after compounds treatment. Next, the Aβ accumulation in the neurons was also detected via employing the western blotting assay. |
| Databáze: | OpenAIRE |
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