High-fat diet increases NF-κB signaling in the prostate of reporter mice
| Autor: | Olena Vykhovanets, Sanjay Gupta, Eswar Shankar, Eugene V. Vykhovanets, Sanjeev Shukla |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
NADPH oxidase biology business.industry Urology Cancer NF-κB Prostatic Diseases NFKB1 medicine.disease_cause medicine.disease chemistry.chemical_compound Endocrinology medicine.anatomical_structure Oncology chemistry Prostate Internal medicine biology.protein Medicine Signal transduction business Oxidative stress |
| Zdroj: | The Prostate. 71:147-156 |
| ISSN: | 0270-4137 |
| Popis: | Background High-fat diet (HFD) is considered as a major risk factor for benign prostatic diseases and cancer in the Western world. Studies have shown an association between oxidative stress and prostatic diseases. NF-κB has been implicated in stress response and is deregulated in prostrate disorders; therefore, we sought to determine whether HFD could induce oxidative stress in the prostate which could contribute to prostatic diseases. |
| Databáze: | OpenAIRE |
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