Fluoxetine-induced Stevens-Johnson syndrome and liver injury
| Autor: | Bashar M. Attar, Seema R. Gandhi, Rohit Agrawal, Anas Almoghrabi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Liver injury medicine.medical_specialty Fluoxetine medicine.diagnostic_test business.industry medicine.disease 030226 pharmacology & pharmacy Rash Gastroenterology stomatognathic diseases 03 medical and health sciences 0302 clinical medicine Fulminant hepatic failure Internal medicine Concomitant medicine Abnormal Liver Function Test Pharmacology (medical) 030212 general & internal medicine medicine.symptom Adverse effect Liver function tests business medicine.drug |
| Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 44:115-118 |
| ISSN: | 0269-4727 |
| DOI: | 10.1111/jcpt.12760 |
| Popis: | What is known and objective Drug-induced liver injuries (DILI) are overall rare and often associated with use of medications. Medications are also the most common aetiology of Stevens-Johnson syndrome (SJS), but SJS is seldom seen concomitantly with liver injury. Many common drugs can cause either one of these conditions; however, there are no reported cases of concomitant DILI and SJS secondary to fluoxetine. Case summary A 41-year-old female presented with a skin rash and abnormal liver function tests after the recent initiation of fluoxetine. Skin and liver biopsies showed features of SJS and DILI, respectively. Fluoxetine was stopped, following which there was improvement in her liver function tests and skin rash, without progression to fulminant hepatic failure. What is new and conclusion Commonly used and safe pharmaceuticals such as fluoxetine have the potential for serious adverse events affecting the skin and liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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