Structural analysis of the complex of phenoxazone antibiotic actinocyl-bis(2-dimethylaminoethyl)amide with deoxytetranucleotide 5′-d(TpGpCpA) by two-dimensional 1H-NMR spectroscopy and molecular mechanics

Autor:	Alexei N. Veselkov, L. N. Djimant, Kyrill A. Veselkov, David B. Davies
Rok vydání:	2005
Předmět:	chemistry.chemical_compound Crystallography Aqueous solution chemistry Structural Biology Amide Intercalation (chemistry) Biophysics Nuclear magnetic resonance spectroscopy Chromophore Spectroscopy Molecular mechanics DNA
Zdroj:	Molecular Biology. 39:298-305
ISSN:	1608-3245 0026-8933
DOI:	10.1007/s11008-005-0042-8
Popis:	The spatial structure of an intercalated complex of the synthetic phenoxazone antibiotic actinocyl-bis-(2-dimethylaminoethyl)amide (ActII) and the self-complementary deoxytetranucleotide 5′-d(TpGpCpA) was studied using two-dimensional NMR (2D-NOESY) spectroscopy of the complex in an aqueous solution and molecular mechanics simulation. Distinctive features of the conformation of ActII-DNA complexes were determined for two possible orientations of the ActII chromophore at the intercalation site.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dfbf23a01084dea27fc3799c5440bb9b https://doi.org/10.1007/s11008-005-0042-8 Zobrazit plný text záznamu Full text from SpringerLink