THE INFLUENCE OF CERTAIN DRUGS ON THE CRUSTACEAN NERVE-MUSCLE SYSTEM

Autor:	C. H. Thienes, C. H. Ellis, C. A. G. Wiersma
Rok vydání:	1942
Předmět:	medicine.anatomical_structure Refractory period medicine Excitatory postsynaptic potential Stimulation Nerve fiber Biology Axon Pharmacology General Agricultural and Biological Sciences Crayfish Inhibitory postsynaptic potential Peripheral
Zdroj:	The Biological Bulletin. 83:334-352
ISSN:	1939-8697 0006-3185
DOI:	10.2307/1538232
Popis:	The effects of a wide selection of drugs on the peripheral nerve-muscle preparations of the cheliped of the crayfish, Cambarus clarkii, were studied.Of all drugs used, the local anaesthetics were the only ones which, as a group, showed the customary vertebrate effects on crustacean preparations.In general, the effects of the drugs used in the investigation were limited to changes in the excitability of the nerve fiber. These effects were of two types; either the refractory period of the nerve was markedly lengthened, or the nerve fiber became so hypersensitive that excitatory stimuli set up multiple discharges in the nerve.The effects of the drugs on peripheral inhibition were studied, with the conclusion that the substances exert little effect on the mechanisms involved in these phenomena, especially on those responsible for supplementary inhibition.An investigation was made into certain "reversal" effects in which stimulation of the inhibitory axon showed an excitation, and in which stimulation of the e...
Databáze:	OpenAIRE
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