Nanocrystalline hydroxyapatite doped with aluminium: A potential carrier for biomedical applications
| Autor: | G. L. Agawane, Veeresh T. Magalad, Mahesh A. Shinde, Jin Hyeok Kim, Tanaji V. Kolekar, Hemraj M. Yadav, Nanasaheb D. Thorat, Sneha S. Bandgar |
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| Rok vydání: | 2016 |
| Předmět: |
Nanocomposite
Materials science Biocompatibility Scanning electron microscope Process Chemistry and Technology Nanoparticle chemistry.chemical_element Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Nanocrystalline material 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Transmission electron microscopy Aluminium Materials Chemistry Ceramics and Composites 0210 nano-technology Thermal analysis |
| Zdroj: | Ceramics International. 42:5304-5311 |
| ISSN: | 0272-8842 |
| DOI: | 10.1016/j.ceramint.2015.12.060 |
| Popis: | Biocompatible materials based on hydroxyapatite are potentially attractive for a wide range of medical applications. The effect of aluminium substitution on the biocompatibility of hydroxyapatite (HA) under the physiochemical conditions has been investigated. Various samples of aluminium doped hydroxyapatite (Al-HA) with different concentration (0, 0.5, 1.0, 1.5, 2.0, 2.5 mol%) were successfully synthesised by solution combustion method and characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Scanning Electron Microscopy (SEM), and thermal analysis technique. XRD and TEM results reveal uniform and crystalline nature of Al-HA nanoparticles. The biocompatibility of the Al-HA nanoparticles was studied using L929 cell lines by MTT assays up to 24 h. These Al-HA nanoparticles are biocompatible on cell lines L929 and do not have toxic effects for further possible in vivo applications. The results of these studies confirmed the biocompatibility of Al-HA and demonstrated the suitability for biomedical applications. The present work reveals the importance of structural, morphological, biocompatible properties of Al-HA nanoparticles and predicts the suitability for biomedical applications. |
| Databáze: | OpenAIRE |
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