Increased risk for aplastic anemia and myelodysplastic syndrome in individuals lacking glutathione S-transferase genes
| Autor: | Neal S. Young, Michael W. Stacey, W.G. Kearns, Joanne F. Sutton, Johnson M. Liu, Thomas S. Rieg |
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| Rok vydání: | 2003 |
| Předmět: |
education.field_of_study
biology business.industry Anemia Population Bone marrow failure Hematology medicine.disease Glutathione S-transferase Oncology hemic and lymphatic diseases Chromosome instability Pediatrics Perinatology and Child Health Immunology Genotype biology.protein Medicine Risk factor Aplastic anemia business education |
| Zdroj: | Pediatric Blood & Cancer. 42:122-126 |
| ISSN: | 1545-5009 |
| DOI: | 10.1002/pbc.10479 |
| Popis: | Background Aplastic anemia (AA) and myelodysplastic syndrome (MDS) are marrow failure states that may be associated with chromosomal instability. An absence of the glutathione S-transferase (GST) enzyme may genetically predispose individuals to AA or MDS. Procedure and Results To test this hypothesis, we determined the GSTM1 and GSTT1 genotypes in a total of 196 patients using multiplex PCR. The GSTT1 null genotype was found to be overrepresented in Caucasian, Asian, and Hispanic patients with either AA or MDS. We confirmed a difference in the expected frequency of the GSTM1 null genotype in Caucasian MDS patients. The double null GSTM1/GSTT1 genotype was also overrepresented in Caucasian AA and MDS patients. In our population, 26% of AA patients and 40% of MDS patients had a chromosomal abnormality identified by karyotype or FISH analyses for chromosomes 7 and 8. Patients with AA and the GSTT1 null genotype had an increased frequency of chromosomal abnormalities (P = 0.003). Conclusion There seems to be an increased risk for AA and MDS in individuals lacking GSTT1 or both GSTM1/GSTT1. Published 2003 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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