Ein Extrakt aus Pelargonium sidoides (EPs® 7630) beeinflusst die Wechselwirkungen zwischen A-Streptokokken und Wirtsepithelien

Autor:	Andreas Conrad, Uwe Frank, Diana Bauer, Felipe Carrapatoso, Irina Jung, Inge Engels, Caroline Lallemand
Rok vydání:	2008
Předmět:	Pharmacology Bacterial colonization Complementary and alternative medicine Respiratory tract infections Geranium Pelargonium sidoides Biology biology.organism_classification In vitro Bacteria Microbiology
Zdroj:	Zeitschrift für Phytotherapie. 29:19-22
ISSN:	1438-9584 0722-348X
Popis:	EXTRACT OF PELARGONIUM SIDOIDES (EPS® 7630) INHIBITS THE INTERACTIONS OF GROUP A-STREPTOCOCCI AND HOST EPITHELIAEPs ® 7630 is an extract of the root of the South African geranium PELARGONIUM SIDOIDES. Clinical data have shown that this herbal drug preparation can be used to treat upper respiratory tract infections (URTI). The objective of this study was to investigate the impact of EPs ® 7630 on group A-streptococci (GAS) adhering to and invading host epithelial cells in vitro. HEp-2 cells and buccal epithelial cells (BEC) were used as substrata. In conclusion, EPs ® 7630 develops complementary anti-infective properties: Firstly, EPs ® 7630 reduces bacterial adhesion to intact epithelial cells and thus protects the organism from bacterial colonization and infection/super-infection. Secondly, EPs ® 7630 enhances the attachment of bacteria to decaying BEC. In this way pathogens may be trapped and rendered inactive. Thus, our investigations provide a rational basis for the treatment of URTI with EPs ® 7630.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dfae9cca0481f18a2ab1245be72cc9fe https://doi.org/10.1055/s-2008-1064943 Zobrazit plný text záznamu