| Popis: |
after a 60 min resting period with a barostat device (Distender, G&J • G3162 Electronics, Canada). Two hours after administration of the study medication, a blood sample was taken for determination of cisapride plasma levels. Results: In subjects treated with cisapride, 2 hour after administration of cisapride, plasma levels were between 18.0 and 89.9 ng/mL (mean 61.2 _+ 7.7 mg/mL). Comparing values before and after Cisapride administration, neither volume (154-+ 56 vs. 188 -+ 59 mL) nor pressure values (8.2 -+ 0.5 vs. 8.8 -+ 0.5 mmHg, p all >0.6) for first perception were changed. Similarly, during random ramp distension cisapride did not alter visceral thresholds for first perception (15.8 -+ 0.8 vs. 15.9 -+ 0.6) and maximal tolerated pressure (22.0 -+ 1.1 vs. 21.94 -+ 0.7, p>0.5). No significant changes of the volumes during first perception (444 -+ 85 vs. 417 -+ 86, p>0.5) and maximal tolerated distension (884 -+ 98 vs. 929 -+ 75, p >0.5) occurred. Interestingly, sensory thresholds tended to be lower in subjects with symptoms compared to asymptomatic subjects (p |
