CYTOKINE STATUS OF WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS IN DYNAMICS OF TREATMENT WITH ALENDRONAT

Autor:	E. A. Maylyan, A. V. Churilov, I. G. Nemsadze, Z. S. Rumyantceva, I. S. Glazkov
Rok vydání:	2021
Předmět:	musculoskeletal diseases Industrial and Manufacturing Engineering
Zdroj:	Crimea Journal of Experimental and Clinical Medicine. 11:5-11
ISSN:	2224-6452 2224-6444
Popis:	The aim of work was to study blood serum concentrations of tumor necrosis factor alpha (TNF-α), interleukins (IL) -1β, -6, -10, -17A, osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) in dynamics of alendronic acid-based treatment in women with postmenopausal osteoporosis with. 136 women with postmeno- pausal osteoporosis were examined in dynamics of treatment with alendronate. Treatment duration was 12 months. TNF-α, IL-1β, IL-6, IL-10, IL-17A, OPG and RANKL serum concentrations were studied in all patients before and after treatment. Molecular genetic studies included real-time PCR testing of ESR1 gene rs2234693 polymorphisms and IL-6 gene rs1800795 one. Women with postmenopausal osteoporosis had increased serum IL-1β and IL-6 concentra- tions before and after therapy (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::df9c33bcfbe3286757f024084f583390 https://doi.org/10.37279/2224-6444-2021-11-1-5-11 Zobrazit plný text záznamu