Red blood cell distribution width predicts homocysteine levels in adult population without vitamin B12 and folate deficiencies
| Autor: | You-Fan Peng, Guo-Gang Pan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Creatinine Homocysteine medicine.diagnostic_test biology business.industry C-reactive protein Red blood cell distribution width 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology chemistry 030220 oncology & carcinogenesis Internal medicine medicine Absolute neutrophil count biology.protein Population study Vitamin B12 Cardiology and Cardiovascular Medicine business Mean corpuscular volume |
| Zdroj: | International Journal of Cardiology. 227:8-10 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2016.11.012 |
| Popis: | Objectives Our aim in this study was to explore the relationship between red blood cell distribution width (RDW) and homocysteine levels in an adult population. Methods The study included 344 subjects who underwent health check-up in our hospital. The demographic characteristics and laboratory parameters of participants were grouped in accordance with tertiles of RDW. Results An increase of homocysteine levels was found from the first to third tertiles of RDW in all participants. There was a positive correlation between RDW and homocysteine ( r =0.227, P 0.001) in all participants. After adjustment for gender, age, neutrophil count (NC), lymphocyte count (LC), hemoglobin (Hb), mean corpuscular volume (MCV), platelet count (PLC), creatinine (Cr), vitamin B 12 and folate. RDW was found to be strongly associated with homocysteine independently of age, NC, MCV and Hb values in multivariable logistic regression analysis (OR=1.501; 95% CI, 1.290–1.746; P 0.001). Conclusions The findings of the present study suggest that RDW may predict homocysteine levels among the study population, the results may support that elevated RDW should be considered to be a marker of cardiovascular events. However, the results need to be affirmed in future studies with larger samples. |
| Databáze: | OpenAIRE |
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