Modified thrombin receptor-agonist peptide ligands. Synthesis and conformational analysis of analogs of the N-terminal tripeptide region
| Autor: | Masaji Ishiguro, Tetsuo Shimamoto, Seiichi Imajo, Tomoko Miyazaki, Hiroko Tsuboi, Yasuo Kitajima, Yoshiaki Oyama |
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| Rok vydání: | 1995 |
| Předmět: |
chemistry.chemical_classification
Chemistry Ligand Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Peptide Tripeptide Biochemistry Combinatorial chemistry Drug Discovery Thrombin receptor Agonist peptide Molecular Medicine Human Thrombin Receptor Molecular Biology Peptide ligand |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 5:2417-2422 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(95)00421-o |
| Popis: | Analogs 2–24 of the N-terminal tripeptide region of the tethered peptide ligand for human thrombin receptor have been synthesized for elucidation of the receptor bound conformation of the ligand peptide and the conformational analysis of model structures 25–30 of those peptide analogs suggested a plausible conformation for the receptor bound structure of the tripeptide region. Analogs of the N-terminal tripeptide region of the tethered peptide ligand for human thrombin receptor have been synthesized and the conformational analysis of model structures of those peptide analogs suggested a plausible conformation for the receptor bound structure of the tripeptide region. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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